HRT_FEM community practice

Transfeminine HRT — Powers Method

Dr Will Powers' EV monotherapy pathway. High-dose injectable oestradiol to suppress testosterone without anti-androgens, progesterone added rectally for bioavailability. Evidence-based and widely used in the DIY community.

Duration

—

Steps

3

Total Weeks

12

Route

IM

Protocols

2

Source

community practice

Protocol Timeline

Step Weeks Dose Compound Note
1 12 4 mg Estradiol Valerate Transition from oral/sublingual to injectable EV at Tanner stage 3. Start at 4-5 mg/week.
2 0 5 mg Estradiol Valerate Titrate up for E2 monotherapy (target E2 >200 pg/mL to suppress T). Taper and drop anti-androgen once T suppressed.
1 0 100 mg Progesterone (Rectal) 100-200 mg rectally at bedtime. Off-label use of oral capsules. 4-6x higher bioavailability than oral.

Rationale

Blood test at 6–8 weeks to confirm testosterone suppression. If T not suppressed, anti-androgen bridging may be needed temporarily.

Compounds Used

Estradiol Valerate

estradiol_valerate · primary

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Progesterone (Rectal)

progesterone_rectal · support

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Related Tools

Medication Level Plotter

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Dose Calculator

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Split Dose Calculator

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Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.

Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.