GLP-1 clinical practice
Tirzepatide Full Titration
Complete Mounjaro/Zepbound titration from 2.5mg through to 15mg target maintenance. Titrates every 4 weeks per FDA label. Most patients find their sweet spot between 5mg and 10mg.
Duration
—
Steps
8
Total Weeks
20
Route
SubQ
Protocols
3
Source
clinical practice
Protocol Timeline
| Step | Weeks | Dose | Compound | Note |
|---|---|---|---|---|
| 1 | 4 | 2.5 mg | Tirzepatide | Initiation dose — for GI tolerability |
| 2 | 4 | 5 mg | Tirzepatide | First therapeutic dose |
| 3 | 4 | 7.5 mg | Tirzepatide | Increase if additional glycemic control needed |
| 4 | 4 | 10 mg | Tirzepatide | — |
| 5 | 4 | 12.5 mg | Tirzepatide | — |
| 6 | 0 | 15 mg | Tirzepatide | Maximum dose — maintenance |
| 1 | 0 | 10 mg | Tirzepatide | Common target dose from clinical trials |
| 1 | 0 | 15 mg | Tirzepatide | Maximum dose — best weight loss outcomes in SURPASS trials |
Rationale
Tirzepatide acts on both GIP and GLP-1 receptors — GI side effects are similar to semaglutide but may be slightly less pronounced at equivalent efficacy doses.
Compounds Used
Related Tools
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