Semaglutide — Slow Titration (GI-Sensitive)
Semaglutide dose escalation at half-speed for patients with significant GI side effects. Spend 4 weeks at each dose instead of the standard 4-week label schedule. Sacrifices speed of weight loss for tolerability.
Duration
—
Steps
5
Total Weeks
32
Route
SubQ
Protocols
1
Source
clinical practice
Protocol Timeline
| Step | Weeks | Dose | Compound | Note |
|---|---|---|---|---|
| 1 | 8 | 0.25 mg | Semaglutide (Injectable) | Extended initiation |
| 2 | 8 | 0.5 mg | Semaglutide (Injectable) | — |
| 3 | 8 | 1 mg | Semaglutide (Injectable) | — |
| 4 | 8 | 1.7 mg | Semaglutide (Injectable) | — |
| 5 | 0 | 2.4 mg | Semaglutide (Injectable) | Maintenance dose |
Rationale
If GI side effects are severe, hold the current dose for an additional 4 weeks before escalating. It is better to stay at a tolerated dose than to escalate and stop entirely. Most side effects diminish after 4–8 weeks at any given dose.
Compounds Used
Related Tools
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