HRT_FEM clinical practice

Menopause — Oestradiol Only (Post-Hysterectomy)

Oestradiol-only HRT for post-hysterectomy menopause. No progestogen required when there is no uterus. Simpler regimen, no endometrial cancer risk without a uterus.

Duration

—

Steps

2

Total Weeks

6

Route

transdermal

Protocols

1

Source

clinical practice

Protocol Timeline

Step Weeks Dose Compound Note
1 6 100 mcg/day Estradiol Transdermal Patch (Twice-Weekly) 1 x 100 mcg/day patch. Vivelle-Dot: change 2x/week. Climara: change weekly. Check labs at 6 weeks.
2 0 200 mcg/day Estradiol Transdermal Patch (Twice-Weekly) 2-4 patches (200-400 mcg/day) needed for feminizing levels. Lower VTE risk than oral.

Rationale

If uterus is present, progesterone MUST be added to protect the endometrium. Oestradiol-only is appropriate only after hysterectomy. Transdermal preferred over oral for VTE risk profile.

Compounds Used

Estradiol Transdermal Patch (Twice-Weekly)

estradiol_patch_twice_weekly · primary

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Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.