Menopause — Combined HRT (Patches + Progesterone)
Standard combined menopausal HRT: oestradiol patches for symptom relief with cyclical or continuous progesterone for endometrial protection. The NICE 2024 menopause guideline recommends transdermal oestradiol as first-line for lower VTE risk vs oral.
Duration
—
Steps
3
Total Weeks
6
Route
transdermal
Protocols
2
Source
clinical practice
Protocol Timeline
| Step | Weeks | Dose | Compound | Note |
|---|---|---|---|---|
| 1 | 6 | 100 mcg/day | Estradiol Transdermal Patch (Twice-Weekly) | 1 x 100 mcg/day patch. Vivelle-Dot: change 2x/week. Climara: change weekly. Check labs at 6 weeks. |
| 2 | 0 | 200 mcg/day | Estradiol Transdermal Patch (Twice-Weekly) | 2-4 patches (200-400 mcg/day) needed for feminizing levels. Lower VTE risk than oral. |
| 1 | 0 | 100 mg | Progesterone (Oral) | 100-200 mg at bedtime. Sedating — allopregnanolone metabolite. Added at Tanner stage 3-4 for breast maturation. |
Rationale
Sequential (cyclical) progesterone if still having periods or within 12 months of last period. Continuous combined for those >12 months post-menopause. Micronised progesterone (Utrogestan) preferred over synthetic progestogens for better cardiovascular and breast safety profile.
Compounds Used
Related Tools
Track this regimen in Doseline
Adopt Menopause — Combined HRT (Patches + Progesterone) as a template, set reminders for every step, and log doses as you go. All free, all private.
Join the waitlistDoseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.