GLP-1 Switch — Tirzepatide → Semaglutide
Transition protocol from tirzepatide to semaglutide — typically due to cost, supply, or insurance coverage change. Approximate dose equivalences: tirzepatide 5mg ≈ semaglutide 0.5mg; tirzepatide 10mg ≈ semaglutide 1mg; tirzepatide 15mg ≈ semaglutide 2mg. Expect temporary appetite increase during transition.
Duration
—
Steps
10
Total Weeks
32
Route
SubQ
Protocols
2
Source
clinical practice
Protocol Timeline
| Step | Weeks | Dose | Compound | Note |
|---|---|---|---|---|
| 1 | 4 | 2.5 mg | Tirzepatide | Initiation dose — for GI tolerability |
| 2 | 4 | 5 mg | Tirzepatide | First therapeutic dose |
| 3 | 4 | 7.5 mg | Tirzepatide | Increase if additional glycemic control needed |
| 4 | 4 | 10 mg | Tirzepatide | — |
| 5 | 4 | 12.5 mg | Tirzepatide | — |
| 6 | 0 | 15 mg | Tirzepatide | Maximum dose — maintenance |
| 1 | 4 | 0.25 mg | Semaglutide (Injectable) | Initiation dose — for GI tolerability, not therapeutic |
| 2 | 4 | 0.5 mg | Semaglutide (Injectable) | First therapeutic dose |
| 3 | 4 | 1 mg | Semaglutide (Injectable) | Standard target dose — increase if additional glycemic control needed |
| 4 | 0 | 2 mg | Semaglutide (Injectable) | Maximum dose — maintenance |
Rationale
No washout period needed — can switch directly. Start semaglutide at a dose below the approximate equivalent to allow GI readjustment. Weight regain risk is real during transition — manage expectations.
Compounds Used
Related Tools
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