GLP-1 Switch — Liraglutide → Semaglutide
Transition from liraglutide (Saxenda, daily injection) to semaglutide (Ozempic/Wegovy, weekly injection). Semaglutide produces superior weight loss at equivalent or lower doses and requires only weekly injections vs daily.
Duration
—
Steps
9
Total Weeks
16
Route
SubQ
Protocols
2
Source
clinical practice
Protocol Timeline
| Step | Weeks | Dose | Compound | Note |
|---|---|---|---|---|
| 1 | 1 | 0.6 mg | Liraglutide | — |
| 2 | 1 | 1.2 mg | Liraglutide | — |
| 3 | 1 | 1.8 mg | Liraglutide | — |
| 4 | 1 | 2.4 mg | Liraglutide | — |
| 5 | 0 | 3 mg | Liraglutide | Maintenance dose — evaluate weight loss at 12 weeks |
| 1 | 4 | 0.25 mg | Semaglutide (Injectable) | Initiation dose — for GI tolerability, not therapeutic |
| 2 | 4 | 0.5 mg | Semaglutide (Injectable) | First therapeutic dose |
| 3 | 4 | 1 mg | Semaglutide (Injectable) | Standard target dose — increase if additional glycemic control needed |
| 4 | 0 | 2 mg | Semaglutide (Injectable) | Maximum dose — maintenance |
Rationale
Can switch directly on the day of next scheduled liraglutide injection. Start semaglutide at 0.25mg for 4 weeks regardless of liraglutide dose. Daily injection burden reduction is a major quality-of-life improvement for most patients.
Compounds Used
Related Tools
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