EV Monotherapy (High-Dose Clinical)
High-dose estradiol valerate monotherapy targeting oestradiol levels high enough to suppress testosterone without any anti-androgen. Clinical version — biweekly schedule as prescribed. See community regimen C4 for DIY every-5-day variant.
Duration
—
Steps
2
Total Weeks
—
Route
IM
Protocols
2
Source
clinical practice
Protocol Timeline
| Step | Weeks | Dose | Compound | Note |
|---|---|---|---|---|
| 1 | 0 | 6 mg | Estradiol Valerate | Aims for E2 >200 pg/mL to suppress T without anti-androgen. 6-10 mg every 5-7 days. |
| 1 | 0 | 100 mg | Progesterone (Oral) | 100-200 mg at bedtime. Sedating — allopregnanolone metabolite. Added at Tanner stage 3-4 for breast maturation. |
Rationale
T suppression via oestradiol alone requires trough E2 above ~200 pg/mL consistently. Biweekly clinical schedule causes significant peak-trough variation — some patients prefer every-5-day community schedule. Monitor VTE risk.
Compounds Used
Related Tools
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