EV Injection Monotherapy — DIY Community
Estradiol Valerate injection monotherapy per community consensus: 4–7mg every 5 days (IM) targeting trough E2 >200 pg/mL to suppress testosterone without an anti-androgen. The community-driven approach to transfeminine HRT — higher estradiol targets than clinical guidelines. Every-5-day schedule is community standard; clinical biweekly schedule causes unacceptable level swings.
Duration
—
Steps
2
Total Weeks
—
Route
IM
Protocols
2
Source
community practice
Protocol Timeline
| Step | Weeks | Dose | Compound | Note |
|---|---|---|---|---|
| 1 | 0 | 6 mg | Estradiol Valerate | Aims for E2 >200 pg/mL to suppress T without anti-androgen. 6-10 mg every 5-7 days. |
| 1 | 0 | 100 mg | Progesterone (Oral) | 100-200 mg at bedtime. Sedating — allopregnanolone metabolite. Added at Tanner stage 3-4 for breast maturation. |
Rationale
Blood draw ALWAYS at trough (immediately before next injection). Every 3 months initially, then every 6–12 months stable. If trough T not suppressed (<50 ng/dL), dose must increase. Monitor VTE risk. Sources: r/TransDIY, diyhrt.wiki, Transfeminine Science. Differs from R28 (clinical) by dosing schedule and target levels.
Compounds Used
Related Tools
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