Triptorelin

Trelstar · Decapeptyl

GnRH Agonist HRT IM FDA/EMA Label

Half-life

30 days

Time to Peak

4 hr

Steady State

~150 days

Bioavailability

100%

Dose Range

3.75–22.5 mg

Frequency

Monthly

Overview

GnRH agonist depot injection. Available in 1-month (3.75 mg), 3-month (11.25 mg), and 6-month (22.5 mg) depot formulations. Same mechanism as leuprolide -- continuous GnRH receptor stimulation leads to downregulation and gonadal suppression. Free peptide half-life ~2.8h; depot models sustained release.

Mechanism of Action

Synthetic decapeptide GnRH agonist. Continuous administration downregulates pituitary GnRH receptors, suppressing LH, FSH, and downstream sex hormone production.

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Intramuscular (IM)	3.75–22.5 mg	30 days	4 hr	Monthly, Every 3 months, Every 6 months

Used in Regimens

Triptorelin is not currently part of any catalog regimen.

Data Sources

FDA Label Trelstar (triptorelin pamoate) FDA Prescribing Information

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