TB-500

Thymosin Beta-4 · TB4

Peptide peptide SubQ Published Clinical Data

Half-life

2.5 hr

Time to Peak

45 min

Steady State

~1 days

Dose Range

2–5 mg

Frequency

Twice weekly

Overview

TB-500 is a synthetic fraction of Thymosin Beta-4, a naturally occurring peptide involved in tissue repair, cell migration, and angiogenesis. Used primarily for injury recovery and healing support in the biohacking community.

Mechanism of Action

Promotes cell migration and differentiation, upregulates actin polymerization, reduces inflammation, and stimulates new blood vessel formation (angiogenesis). Works synergistically with BPC-157 through complementary healing pathways.

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Subcutaneous (SubQ)	2–5 mg	2.5 hr	45 min	Twice weekly, three times weekly

Common Side Effects

· Injection site irritation
· Headache (uncommon)
· Fatigue (uncommon)
· Generally well-tolerated in reported use

Monitoring Recommendations

No established monitoring protocol. Consider baseline CBC and CMP.

Storage & Handling

Refrigerated

Reconstituted: 28-30 days refrigerated

Room Temperature

Lyophilized (powder): stable at room temperature for months

General

Reconstitute with bacteriostatic water. Refrigerate after reconstitution.

Community Notes

Loading phase of 5-10mg/week for 4-6 weeks is common, followed by a maintenance dose of 2-5mg every 1-2 weeks. Often stacked with BPC-157. SubQ injection anywhere works — it's a systemic peptide, not site-specific like BPC-157.

Used in Regimens

1 regimen

BPC-157 + TB-500 Healing Stack

The classic peptide healing stack. BPC-157 accelerates soft tissue, tendon, and gut repair while TB-500 promotes angiogenesis and systemic muscle recovery. Typically run for 4–8 weeks per course.

TB-500 at 2–5mg twice weekly during loading phase, then weekly maintenance

8wk peptide

Ancillary

Data Sources

Peer-reviewed Thymosin Beta-4 pharmacology and tissue repair mechanisms

Related Tools

Medication Level Plotter

See blood level curves for this compound

Dose Calculator

Calculate reconstitution and draw volumes

Split Dose Calculator

Divide your weekly dose into multiple injections

Track TB-500 with Doseline

Reminders, medication level charts, injection site rotation, and protocol tracking — all free, all private.

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