Tamoxifen
Nolvadex
Half-life
6 days
Time to Peak
5 hr
Steady State
~30 days
Dose Range
10–40 mg
Frequency
Daily
Overview
The most widely used SERM for PCT and gynecomastia prevention. Blocks estrogen at the breast receptor while acting as an agonist in bone. Long half-life means once-daily dosing.
Mechanism of Action
Selective estrogen receptor modulator — antagonist at breast tissue ER, agonist at bone/uterine ER. Blocks estrogen-mediated negative feedback on the hypothalamus during PCT, stimulating LH/FSH release.
Dosing Information
| Route | Dose Range | Half-life | Tmax | Frequency |
|---|---|---|---|---|
| Oral | 10–40 mg | 6 days | 5 hr | Daily |
Used in Regimens
10 regimensBeginner First Cycle (Harm Reduction)
Conservative beginner AAS cycle for harm reduction: testosterone-only at moderate dose with on-cycle HCG and post-cycle Nolvadex. Designed to minimise risk while providing meaningful data about individual response to testosterone before adding other compounds.
Nolvadex PCT start 14 days after last injection.
Beginner Test-Only Blast + PCT
12-week testosterone cypionate blast at beginner doses with on-cycle HCG for testicular maintenance, followed by a 2-week clearance window and 4-week Nolvadex PCT. The gold-standard first cycle.
Start Nolvadex 2 weeks after last testosterone injection to allow clearance
Scally PoWeR PCT
Dr Michael Scally's Power of Will and Endurance Recovery (PoWeR) PCT protocol. The most aggressive, evidence-based PCT: HCG blast to prime the testes, then concurrent Clomid + Nolvadex for maximal HPTA stimulation. Used after long/heavy cycles or blast and cruise transitions.
Nolvadex 20mg/day concurrent with Clomid.
Standard Nolvadex PCT
Tamoxifen (Nolvadex) post-cycle therapy following a testosterone or AAS cycle. SERM blocks oestrogen receptors at the hypothalamus, stimulating LH/FSH release and endogenous testosterone recovery. Modern r/steroids wiki recommends lower doses for longer duration vs the older 40/40/20/20 protocol.
Nolvadex PCT — start 14 days after last pin.
Test/Anavar Lean Cycle
Testosterone cypionate base with Oxandrolone (Anavar) for a lean mass/strength cycle. Anavar is mild, low-androgenic, and well-tolerated — popular for first compound additions. TUDCA liver support required as Anavar is an oral 17-alpha-alkylated steroid.
Nolvadex PCT start 2 weeks after last test pin.
Test/Deca Bulk Cycle
Testosterone enanthate + Nandrolone Decanoate (Deca) classic bulk cycle. One of the most popular intermediate AAS stacks. Deca adds significant mass with less androgenic side effects than testosterone alone. Requires HCG on-cycle, an AI if needed, cabergoline for prolactin, and full PCT.
Nolvadex PCT starting 2 weeks after last injection.
Data Sources
Related Tools
Track Tamoxifen with Doseline
Reminders, medication level charts, injection site rotation, and protocol tracking — all free, all private.
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