Tadalafil
Cialis · Adcirca · Alyq
Half-life
17.5 hr
Time to Peak
2 hr
Steady State
~4 days
Dose Range
2.5–20 mg
Frequency
Daily
Overview
PDE5 inhibitor. FDA-approved for erectile dysfunction and pulmonary arterial hypertension. Very widely used in the TRT and AAS community for multiple purposes: (1) Erectile function and sexual performance during or after cycle. (2) Daily low-dose (2.5–5mg) for cardiovascular benefits — reduces blood pressure, improves endothelial function, and may offset AAS-induced hypertension. (3) Some users report improved muscle pumps and vascularity via vasodilation. The longest-acting PDE5 inhibitor (~36-hour effective duration) — most popular in the community for daily use due to once-daily convenience. Harm reduction: Do not combine with nitrates (severe hypotension risk). Monitor blood pressure. At 5mg/day dose, cardiovascular profile is very well tolerated.
Mechanism of Action
Selective phosphodiesterase type 5 (PDE5) inhibitor. PDE5 normally degrades cGMP in vascular smooth muscle — inhibition maintains elevated cGMP, causing vasodilation. Effects systemic (blood pressure reduction) and tissue-specific (penile, pulmonary).
Dosing Information
| Route | Dose Range | Half-life | Tmax | Frequency |
|---|---|---|---|---|
| Oral | 2.5–20 mg | 17.5 hr | 2 hr | Daily, As needed |
Storage & Handling
Room temperature — Store at 25C (77F); excursions permitted to 15-30C. Protect from moisture.
Used in Regimens
Tadalafil is not currently part of any catalog regimen.
Data Sources
- FDA Label Cialis (tadalafil) FDA Prescribing Information
Related Tools
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