SS-31 (Elamipretide)
Elamipretide
Half-life
3.5 hr
Time to Peak
45 min
Steady State
~1 days
Dose Range
20–60 mg
Frequency
Daily
Overview
Synthetic mitochondria-targeted tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2). Concentrates in the inner mitochondrial membrane where it stabilizes cardiolipin and improves electron transport chain efficiency. In clinical trials for Barth syndrome and other mitochondrial diseases. One of the better-characterized mitochondrial peptides. Requires reconstitution with BAC water.
Mechanism of Action
Selectively targets and accumulates in the inner mitochondrial membrane. Stabilizes cardiolipin, optimizes electron transport chain function, reduces reactive oxygen species (ROS) production, and improves mitochondrial ATP output.
Dosing Information
| Route | Dose Range | Half-life | Tmax | Frequency |
|---|---|---|---|---|
| Subcutaneous (SubQ) | 20–60 mg | 3.5 hr | 45 min | Daily |
Storage & Handling
2-8C — Store lyophilized powder refrigerated. Reconstitute with BAC water or sterile water.
Used in Regimens
SS-31 (Elamipretide) is not currently part of any catalog regimen.
Data Sources
- Peer-reviewed Elamipretide (SS-31) Phase I/II pharmacokinetics
Related Tools
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