Semax

Peptide peptide Nasal SubQ Published Clinical Data

Half-life

3 min

Time to Peak

2 min

Steady State

~1 days

Dose Range

200–1200 mcg

Frequency

Daily

Overview

Synthetic analog of the adrenocorticotropic hormone (ACTH) fragment 4-10 with added Pro-Gly-Pro C-terminal tripeptide for stability. Developed in Russia and approved there for cognitive enhancement, stroke recovery, and neuroprotection. Primarily administered intranasally. Very short half-life but extended neurological effects. Requires reconstitution for injectable use.

Mechanism of Action

Increases BDNF and NGF expression, modulates serotonergic and dopaminergic systems, and has neuroprotective properties. Enhances attention, memory, and cognitive performance.

Dosing Information

Route Dose Range Half-life Tmax Frequency
Nasal 200–1200 mcg 3 min 2 min Daily, Twice daily, three times daily
Subcutaneous (SubQ) 200–1200 mcg 3 min 2 min Daily, Twice daily

Storage & Handling

2-8C — Store refrigerated. Primarily used intranasally. Reconstitute with BAC water for SubQ use.

Used in Regimens

1 regimen

Semax + Selank Nootropic Stack

Semax (ACTH-derived nootropic) paired with Selank (anxiolytic peptide) — the classic Russian nootropic stack. Semax for cognitive enhancement and focus; Selank for anxiety reduction and GABAergic modulation. Both intranasal. Used in the Russian medical system since the 1990s.

Semax intranasal 300–600mcg/day AM.

4wk peptide
Primary

Data Sources

  • Peer-reviewed Semax neuroprotective and cognitive enhancement profile

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Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.