Semaglutide (Oral)

Rybelsus

GLP-1 Receptor Agonist GLP-1 Weight Loss Oral FDA/EMA Label

Half-life

6.7 days

Time to Peak

1 hr

Steady State

~34 days

Bioavailability

Dose Range

3–14 mg

Frequency

Daily

Overview

Once-daily oral GLP-1 receptor agonist for type 2 diabetes. Same molecule as Ozempic/Wegovy but with extremely low oral bioavailability (~1%). Must be taken fasting with minimal water.

Mechanism of Action

Same semaglutide molecule co-formulated with SNAC (sodium salcaprozate) absorption enhancer for oral delivery.

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Oral	3–14 mg	6.7 days	1 hr	Daily

Storage & Handling

20-25C — Room temperature. Keep in blister packaging until use. Protect from moisture.

Used in Regimens

Semaglutide (Oral) is not currently part of any catalog regimen.

Data Sources

FDA Label Rybelsus FDA Prescribing Information

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