PT-141 (Bremelanotide)

Vyleesi · Bremelanotide

Peptide peptide SubQ FDA/EMA Label

Half-life

2.7 hr

Time to Peak

1 hr

Steady State

~1 days

Dose Range

0.5–2 mg

Frequency

As needed

Overview

FDA-approved melanocortin-4 receptor agonist for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women (brand name Vyleesi). Works through the central nervous system rather than the vascular system. Also used off-label across all genders for sexual dysfunction. Auto-injector pen available commercially; compounded versions require reconstitution with BAC water.

Mechanism of Action

Activates melanocortin-4 (MC4) receptors in the central nervous system to increase sexual desire. Unlike PDE5 inhibitors, it works on the brain rather than peripheral vasculature.

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Subcutaneous (SubQ)	0.5–2 mg	2.7 hr	1 hr	As needed

Storage & Handling

2-8C — Vyleesi auto-injector: store refrigerated. Compounded: reconstitute with BAC water. Administer at least 45 minutes before anticipated sexual activity.

Used in Regimens

1 regimen

PT-141 — Sexual Wellness (FDA Standard)

Bremelanotide (PT-141) FDA-approved as-needed treatment for hypoactive sexual desire disorder in premenopausal women (Vyleesi). Used off-label in all genders for libido enhancement. Melanocortin receptor agonist — central mechanism, not vascular.

FDA standard 1.75mg SubQ as-needed. Community: start at 0.5–1mg.

peptide

Primary

Data Sources

FDA Label Vyleesi (Bremelanotide) FDA Prescribing Information

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