Nafarelin

Synarel

GnRH Agonist Nasal FDA/EMA Label

Half-life

3 hr

Time to Peak

30 min

Steady State

~1 days

Bioavailability

3%

Dose Range

200–400 mcg

Frequency

Twice daily

Overview

GnRH agonist administered as an intranasal spray. Indicated for endometriosis and central precocious puberty. Each spray delivers 200 mcg. Unlike depot formulations, requires twice-daily dosing. Bioavailability from nasal mucosa is relatively low (~2-3%), but sufficient for GnRH receptor downregulation at recommended doses.

Mechanism of Action

Synthetic decapeptide GnRH agonist. Absorbed through nasal mucosa. Continuous administration causes pituitary GnRH receptor downregulation.

Dosing Information

Route Dose Range Half-life Tmax Frequency
Nasal 200–400 mcg 3 hr 30 min Twice daily

Used in Regimens

Nafarelin is not currently part of any catalog regimen.

Data Sources

  • FDA Label Synarel (nafarelin acetate) FDA Prescribing Information

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Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.