MOTS-c

Peptide peptide SubQ Case Studies / Guidelines

Half-life

4 hr

Time to Peak

1 hr

Steady State

~1 days

Dose Range

5–15 mg

Frequency

Daily

Overview

Mitochondrial-derived peptide encoded in the 12S rRNA gene of mitochondrial DNA. Naturally produced during exercise. Promotes metabolic homeostasis, insulin sensitivity, and has been shown to prevent obesity in animal models. Used in the longevity/biohacking community. Very limited human PK data. Requires reconstitution with BAC water.

Mechanism of Action

Activates AMPK pathway, improves glucose regulation, enhances fatty acid oxidation, and promotes metabolic homeostasis. Acts as an exercise mimetic at the cellular level.

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Subcutaneous (SubQ)	5–15 mg	4 hr	1 hr	Daily, three times weekly, five days per week

Storage & Handling

2-8C — Store lyophilized powder refrigerated. Reconstitute with BAC water. Use reconstituted solution within 4 weeks.

Used in Regimens

MOTS-c is not currently part of any catalog regimen.

Data Sources

Peer-reviewed MOTS-c mitochondrial-derived peptide metabolic regulation

Related Tools

Medication Level Plotter

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Dose Calculator

Calculate reconstitution and draw volumes

Split Dose Calculator

Divide your weekly dose into multiple injections

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Reminders, medication level charts, injection site rotation, and protocol tracking — all free, all private.

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