MK-677 (Ibutamoren)
Ibutamoren · Nutrobal
Half-life
5 hr
Time to Peak
2 hr
Steady State
~2 days
Dose Range
10–50 mg
Frequency
Daily
Overview
Non-peptide oral GH secretagogue (growth hormone secretagogue receptor agonist). Technically not a peptide, but widely tracked by the peptide community due to its similar mechanism of action. Orally bioavailable — no injection or reconstitution needed. Increases GH and IGF-1 levels for up to 24 hours. Known side effects include increased appetite, water retention, and potential blood sugar elevation. Well-studied in clinical trials but not FDA-approved.
Mechanism of Action
Mimics ghrelin at the GHS-R1a receptor, stimulating sustained GH release from the pituitary. Orally active with high bioavailability. Does not suppress natural GH production.
Dosing Information
| Route | Dose Range | Half-life | Tmax | Frequency |
|---|---|---|---|---|
| Oral | 10–50 mg | 5 hr | 2 hr | Daily |
Storage & Handling
Room temperature — Store capsules/tablets at room temperature. No reconstitution needed — oral dosage form.
Used in Regimens
2 regimensMK-677 + Berberine Insulin Management
MK-677 (Ibutamoren) oral GH secretagogue cycle with Berberine co-administered to counteract MK-677 blood-glucose-raising effects. MK-677 raises IGF-1 and GH pulse amplitude but also increases fasting glucose and reduces insulin sensitivity. Berberine 500mg 2–3x/day with meals activates AMPK to partially offset this.
MK-677 25mg before bed. IGF-1 target 30–60% above baseline. Monitor fasting glucose.
MK-677 Oral GH Secretagogue
MK-677 (Ibutamoren) oral GH secretagogue — increases GH pulse amplitude and IGF-1. Taken orally at bedtime for 12–16 week cycles. Popular for muscle mass, sleep quality, and recovery. Primary concern: blood glucose elevation and increased appetite.
MK-677 25mg before bed. IGF-1 target 30–60% above baseline.
Data Sources
- Peer-reviewed MK-677 (Ibutamoren) clinical pharmacokinetics
Related Tools
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