Melatonin

Other HRT Oral FDA/EMA Label

Half-life

45 min

Time to Peak

30 min

Steady State

~1 days

Bioavailability

15%

Dose Range

0.3–10 mg

Frequency

nightly

Overview

Sleep hormone supplement commonly tracked alongside HRT. Melatonin production can be affected by hormone changes during transition, making supplementation useful. Also used in the broader wellness community.

Mechanism of Action

Endogenous neurohormone produced by the pineal gland in response to darkness. Binds MT1/MT2 receptors in the suprachiasmatic nucleus, regulating circadian rhythm and promoting sleep onset.

Dosing Information

Route Dose Range Half-life Tmax Frequency
Oral 0.3–10 mg 45 min 30 min nightly

Used in Regimens

Melatonin is not currently part of any catalog regimen.

Data Sources

Related Tools

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Track Melatonin with Doseline

Reminders, medication level charts, injection site rotation, and protocol tracking — all free, all private.

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Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.

Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.