KPV

Peptide peptide Oral SubQ Topical Case Studies / Guidelines

Half-life

1 hr

Time to Peak

30 min

Steady State

~1 days

Dose Range

200–1500 mcg

Frequency

Daily

Overview

Anti-inflammatory tripeptide derived from the C-terminal end of alpha-melanocyte stimulating hormone (alpha-MSH). Used for gut inflammation, skin conditions, and general anti-inflammatory purposes. Available via subcutaneous injection, oral capsules, and topical formulations. Limited human PK data. Requires reconstitution with BAC water for injectable use.

Mechanism of Action

Inhibits NF-kB inflammatory pathway activation. Derived from alpha-MSH but lacks melanocortin receptor binding — anti-inflammatory without tanning effects.

Dosing Information

Route Dose Range Half-life Tmax Frequency
Oral 200–1500 mcg 1 hr 30 min Daily, Twice daily
Subcutaneous (SubQ) 200–1000 mcg 1 hr 30 min Daily
Topical 0.5–2 mL 1 hr 30 min Daily, Twice daily

Storage & Handling

2-8C — Store lyophilized powder refrigerated. Reconstitute with BAC water for injection. Also available as oral capsules and topical cream.

Used in Regimens

1 regimen

BPC-157 + KPV Gut Healing Protocol

Oral BPC-157 plus oral KPV for gastrointestinal healing. BPC-157 oral route has demonstrated efficacy for gut tissue repair in animal models. KPV (tripeptide from alpha-MSH) has potent anti-inflammatory effects on gut mucosa — useful for IBD, leaky gut, and post-antibiotic recovery.

KPV oral — gut anti-inflammatory 500mcg–1mg 2x/day.

8wk peptide
Ancillary

Data Sources

  • Peer-reviewed KPV anti-inflammatory tripeptide mechanisms

Related Tools

Medication Level Plotter

See blood level curves for this compound

Dose Calculator

Calculate reconstitution and draw volumes

Split Dose Calculator

Divide your weekly dose into multiple injections

Track KPV with Doseline

Reminders, medication level charts, injection site rotation, and protocol tracking — all free, all private.

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Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.

Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.