Regular Insulin

Humulin R · Novolin R

Other GLP-1 SubQ IV FDA/EMA Label

Half-life

1.5 hr

Time to Peak

2.5 hr

Steady State

~1 days

Bioavailability

55%

Dose Range

1–100 units

Frequency

with meals

Overview

Short-acting human insulin. Slower onset than rapid-acting analogues. Can be given SubQ or IV (only insulin type routinely given IV). Used for mealtime coverage and in insulin drips.

Mechanism of Action

Recombinant human insulin (unmodified sequence). Forms hexamers in solution that must dissociate to monomers before absorption, resulting in slower onset than rapid-acting analogues.

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Subcutaneous (SubQ)	1–100 units	1.5 hr	2.5 hr	with meals, three times daily
Intravenous (IV)	0.1–100 units	6 min	0 min	continuous infusion

Used in Regimens

Regular Insulin is not currently part of any catalog regimen.

Data Sources

FDA Label Humulin R (regular insulin) FDA Prescribing Information

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