Insulin NPH
Humulin N · Novolin N
Half-life
5 hr
Time to Peak
6 hr
Steady State
~2 days
Bioavailability
55%
Dose Range
5–100 units
Frequency
once daily
Overview
Intermediate-acting insulin. Cloudy suspension that must be mixed before injection. Peak action at ~4-10 hours, duration ~12-18 hours. Being replaced by modern long-acting analogues but still widely used globally.
Mechanism of Action
Human insulin complexed with protamine and zinc to form a crystalline suspension. Slow dissolution from subcutaneous depot provides intermediate duration of action.
Dosing Information
| Route | Dose Range | Half-life | Tmax | Frequency |
|---|---|---|---|---|
| Subcutaneous (SubQ) | 5–100 units | 5 hr | 6 hr | once daily, Twice daily |
Used in Regimens
Insulin NPH is not currently part of any catalog regimen.
Data Sources
Related Tools
Track Insulin NPH with Doseline
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