Insulin Glulisine

Apidra

Other GLP-1 SubQ FDA/EMA Label

Half-life

1 hr

Time to Peak

1 hr

Steady State

~1 days

Bioavailability

70%

Dose Range

1–100 units

Frequency

with meals

Overview

Rapid-acting insulin analogue. Third option alongside lispro and aspart for mealtime bolus coverage. Similar pharmacokinetic profile.

Mechanism of Action

Recombinant insulin analogue with asparagine B3 replaced by lysine and lysine B29 replaced by glutamic acid, enabling rapid absorption from subcutaneous depot.

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Subcutaneous (SubQ)	1–100 units	1 hr	1 hr	with meals, three times daily

Used in Regimens

Insulin Glulisine is not currently part of any catalog regimen.

Data Sources

FDA Label Apidra (insulin glulisine) FDA Prescribing Information

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