Insulin Degludec

Tresiba

Other GLP-1 SubQ FDA/EMA Label

Half-life

25 hr

Time to Peak

12 hr

Steady State

~6 days

Dose Range

5–100 units

Frequency

once daily

Overview

Ultra-long-acting basal insulin. Duration >42 hours — the longest-acting insulin available. Very flat profile with lowest day-to-day variability. Flexible dosing timing (8-40 hour window between doses).

Mechanism of Action

Recombinant insulin analogue with C16 fatty diacid side chain acylated to B29 lysine (B30 deleted). Forms soluble multi-hexamer chains at injection site that slowly release monomers over >42 hours.

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Subcutaneous (SubQ)	5–100 units	25 hr	12 hr	once daily

Used in Regimens

Insulin Degludec is not currently part of any catalog regimen.

Data Sources

FDA Label Tresiba (insulin degludec) FDA Prescribing Information

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