IGF-1 LR3
Long R3 IGF-1 · Long-acting IGF-1
Half-life
24 hr
Time to Peak
4 hr
Steady State
~5 days
Dose Range
20–100 mcg
Frequency
Daily
Overview
Modified analog of insulin-like growth factor 1 (IGF-1) with an arginine substitution at position 3 and a 13-amino acid N-terminal extension. These modifications reduce binding to IGF binding proteins (IGFBPs), dramatically extending the effective half-life to ~24 hours compared to ~15 minutes for native IGF-1. Used in bodybuilding and performance communities. Not approved for clinical use. Requires reconstitution with BAC water.
Mechanism of Action
Activates IGF-1 receptor (IGF-1R) to promote cell growth, proliferation, and differentiation. The LR3 modification reduces IGFBP sequestration, resulting in higher free IGF-1 activity and longer duration of action.
Dosing Information
| Route | Dose Range | Half-life | Tmax | Frequency |
|---|---|---|---|---|
| Subcutaneous (SubQ) | 20–100 mcg | 24 hr | 4 hr | Daily |
Storage & Handling
2-8C — Store lyophilized powder frozen or refrigerated. Reconstitute with BAC water. Handle carefully — IGF-1 peptides are sensitive to degradation.
Used in Regimens
IGF-1 LR3 is not currently part of any catalog regimen.
Data Sources
- Peer-reviewed IGF-1 LR3 pharmacokinetics and IGFBP binding characteristics
Related Tools
Track IGF-1 LR3 with Doseline
Reminders, medication level charts, injection site rotation, and protocol tracking — all free, all private.
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