Humanin

HNG · HN

Peptide peptide SubQ Case Studies / Guidelines

Half-life

4 hr

Time to Peak

1 hr

Steady State

~1 days

Dose Range

0.5–5 mg

Frequency

Daily

Overview

Mitochondrial-derived peptide (MDP) encoded in the 16S rRNA region of mitochondrial DNA. First discovered for its neuroprotective properties against Alzheimer disease-related toxicity. Also shows cytoprotective, anti-apoptotic, and metabolic regulatory effects. Very early-stage research with minimal human PK data. Requires reconstitution with BAC water.

Mechanism of Action

Activates STAT3 signaling, inhibits apoptosis via interaction with BAX, and promotes insulin sensitivity through IGFBP-3 interactions. Neuroprotective against amyloid-beta toxicity.

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Subcutaneous (SubQ)	0.5–5 mg	4 hr	1 hr	Daily, three times weekly

Storage & Handling

2-8C — Store lyophilized powder refrigerated. Reconstitute with BAC water. Highly experimental compound.

Used in Regimens

Humanin is not currently part of any catalog regimen.

Data Sources

Peer-reviewed Humanin mitochondrial-derived peptide neuroprotection review

Related Tools

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