Gonadorelin

Factrel

Peptide peptide SubQ IV FDA/EMA Label

Half-life

4 min

Time to Peak

2 min

Steady State

~1 days

Dose Range

50–200 mcg

Frequency

Twice daily

Overview

Synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH). FDA-approved for evaluating pituitary gonadotroph function (diagnostic use). Used by TRT clinics as an alternative to HCG for maintaining testicular function and fertility during testosterone therapy. Very short half-life (~4 minutes) requiring frequent dosing. Supplied as lyophilized powder requiring reconstitution.

Mechanism of Action

Binds GnRH receptors on the anterior pituitary to stimulate release of LH and FSH. Pulsatile administration mimics physiological GnRH secretion. Continuous administration causes receptor downregulation (basis for GnRH agonist drugs).

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Subcutaneous (SubQ)	50–200 mcg	4 min	2 min	Twice daily, three times weekly
Intravenous (IV)	100–100 mcg	4 min	1 min	single dose

Storage & Handling

2-8C — Store lyophilized powder refrigerated. Reconstitute with provided diluent or BAC water. Very short half-life — typically dosed 2x daily or via pump.

Used in Regimens

Gonadorelin is not currently part of any catalog regimen.

Data Sources

FDA Label Factrel (Gonadorelin) FDA Prescribing Information

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