Estradiol Transdermal Patch (Weekly)
Climara
Half-life
1.5 hr
Time to Peak
6 hr
Steady State
~1 days
Bioavailability
5%
Dose Range
25–400 mcg/day
Frequency
Weekly
Overview
Weekly transdermal estradiol patch. Matrix design delivers a continuous, steady dose of estradiol through the skin for 7 days. Bypasses first-pass liver metabolism, resulting in lower VTE risk compared to oral estradiol. For feminizing HRT, most patients need 200-400 mcg/day (multiple patches).
Mechanism of Action
Delivers unmodified 17β-estradiol transdermally. Absorbed through skin into systemic circulation, bypassing hepatic first-pass metabolism.
Dosing Information
| Route | Dose Range | Half-life | Tmax | Frequency |
|---|---|---|---|---|
| Transdermal Patch | 25–400 mcg/day | 1.5 hr | 6 hr | Weekly |
Storage & Handling
Room temperature — Store in sealed pouch until use. Apply to clean, dry skin on abdomen. Avoid waistline. Rotate application sites.
Used in Regimens
Estradiol Transdermal Patch (Weekly) is not currently part of any catalog regimen.
Data Sources
Related Tools
Track Estradiol Transdermal Patch (Weekly) with Doseline
Reminders, medication level charts, injection site rotation, and protocol tracking — all free, all private.
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