Dydrogesterone

Duphaston

Progestogen HRT Oral FDA/EMA Label

Half-life

16 hr

Time to Peak

1.5 hr

Steady State

~4 days

Bioavailability

28%

Dose Range

10–20 mg

Frequency

Daily

Overview

Synthetic retroprogesterone (stereoisomer of progesterone). Widely used in Europe and Asia for HRT and menstrual disorders. Not available in the US. Has selective progesterone receptor agonist activity without androgenic, estrogenic, or glucocorticoid effects -- a cleaner side effect profile than many synthetic progestogens.

Mechanism of Action

Selective progesterone receptor agonist. Retroprogesterone structure provides high oral bioavailability without the extensive first-pass metabolism seen with natural progesterone. Active metabolite 20-alpha-dihydrodydrogesterone also has progestogenic activity.

Dosing Information

Route Dose Range Half-life Tmax Frequency
Oral 10–20 mg 16 hr 1.5 hr Daily, Twice daily

Used in Regimens

Dydrogesterone is not currently part of any catalog regimen.

Data Sources

  • EMA SPC Duphaston (dydrogesterone) EMA Summary of Product Characteristics

Related Tools

Medication Level Plotter

See blood level curves for this compound

Dose Calculator

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Split Dose Calculator

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Track Dydrogesterone with Doseline

Reminders, medication level charts, injection site rotation, and protocol tracking — all free, all private.

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Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.

Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.