Dihexa

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

Peptide peptide Oral Nasal Case Studies / Guidelines

Half-life

2 hr

Time to Peak

1 hr

Steady State

~1 days

Dose Range

5–20 mg

Frequency

Daily

Overview

Synthetic hexapeptide analog of angiotensin IV. Reported to be approximately 10 million times more potent than BDNF at promoting neuronal connections in animal studies. Used in the nootropic/biohacking community for cognitive enhancement. Very limited human data. Available as oral capsules or intranasal solution. Considered highly experimental.

Mechanism of Action

Agonist at the hepatocyte growth factor (HGF) / c-Met receptor system. Promotes synaptogenesis and neuronal connectivity. Derived from angiotensin IV research.

Dosing Information

Route	Dose Range	Half-life	Tmax	Frequency
Oral	5–20 mg	2 hr	1 hr	Daily
Nasal	5–20 mg	2 hr	30 min	Daily

Storage & Handling

2-8C — Store refrigerated. Available as oral capsules or intranasal solution. Highly experimental — limited human safety data.

Used in Regimens

Dihexa is not currently part of any catalog regimen.

Data Sources

Peer-reviewed Dihexa angiotensin IV analog cognitive enhancement in animal models

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