Anastrozole

Arimidex

Aromatase Inhibitor TRT aas Oral FDA/EMA Label

Half-life

2.1 days

Time to Peak

2 hr

Steady State

~11 days

Dose Range

0.25–1 mg

Frequency

Twice weekly

Overview

Non-steroidal aromatase inhibitor for estrogen management on TRT/AAS. Reversible binding — estrogen returns when discontinued.

Mechanism of Action

Reversible competitive inhibitor of aromatase enzyme (CYP19A1), reducing conversion of androgens to estrogens.

Dosing Information

Route Dose Range Half-life Tmax Frequency
Oral 0.25–1 mg 2.1 days 2 hr Twice weekly, Every other day

Used in Regimens

4 regimens

Beginner First Cycle (Harm Reduction)

Conservative beginner AAS cycle for harm reduction: testosterone-only at moderate dose with on-cycle HCG and post-cycle Nolvadex. Designed to minimise risk while providing meaningful data about individual response to testosterone before adding other compounds.

Anastrozole — only if E2 elevated on midcycle bloods.

18wk Harm Reduction aas
Ancillary

Standard TRT Protocol

Evidence-based testosterone replacement with HCG for testicular maintenance and optional low-dose aromatase inhibitor. The most common TRT stack recommended by progressive clinicians.

Use only if oestradiol is symptomatic and above range — many do not need this

trt
Ancillary

Test/Deca Bulk Cycle

Testosterone enanthate + Nandrolone Decanoate (Deca) classic bulk cycle. One of the most popular intermediate AAS stacks. Deca adds significant mass with less androgenic side effects than testosterone alone. Requires HCG on-cycle, an AI if needed, cabergoline for prolactin, and full PCT.

Anastrozole 0.5mg EOD — only if E2 symptomatic on bloods.

20wk Harm Reduction aas
Ancillary

Your First Cycle — r/steroids Wiki

The r/steroids community wiki canonical beginner cycle: 500mg/week testosterone enanthate or cypionate for 15–16 weeks, Nolvadex-only PCT. Deliberately higher dose than clinical harm-reduction guidelines (supraphysiological ~2000–3000+ ng/dL) for visible, measurable gains. The most-referenced beginner AAS protocol in English-speaking communities.

Anastrozole ONLY if E2 symptomatic on labs — do not preemptively dose.

20wk Harm Reduction trt aas
Ancillary

Data Sources

Related Tools

Track Anastrozole with Doseline

Reminders, medication level charts, injection site rotation, and protocol tracking — all free, all private.

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Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.

Doseline provides informational tools only. It is not a medical device and does not provide medical advice. Always consult a qualified healthcare provider.